Similarly, the high DAF in these genomic loci, particularly rs1154413 (ADH5), rs4148887 (ADH4), rs2156733 (ADH6), rs3819197 (ADH1A), rs1229984 (ADH1B), and rs671 (ALDH2) (0.726, 0.734, 0.764, 0.790, 0710 and 0.239, respectively), illustrated corresponding alleles associated with alcoholism in the Han Chinese, when compared with other non-East Asian (Fig. 2b and Supplementary Table 4). Here, ADH4 is linked to alcohol dependence.