MYOD1 and Menkes disease: Remarkably, even Wt mice subjected to AAV-MyoD protein induction from 4 to 6.5 months (Fig. 4g, h) exhibited MD related pathology (i.e., central nucleation, sarcolemmal permeability to IgM, fibrosis, and increased susceptibility to eccentric contraction injury) compared with control AAV infection (Fig. 4i–m).