Yet, in a model of CRC, MHCII+ ILC3 promoted Th1 and cytotoxic CD8+ T cell (CTL) responses in the AOM/DSS model of CRC, restricting cancer progression, as evidenced from the restricted differentiation of Th1 and CTL in Rorc-Cre × H2-Ab1fl/fl mice relative to H2-Ab1fl/fl control mice [8,62]. This evidence concerns the gene CD8A and colorectal carcinoma.