Specifically, upon antibody-mediated depletion of CD90+ ILC in colonic macrophages from DSS-treated mice (and relative to isotype control-treated DSS-treated mice), a reduced ‘M1-like’ RNA sequencing (RNA-seq) transcription signature was noted in macrophages; furthermore, a positive correlation of ILC and CSF2 (encoding GM-CSF) single-cell (sc)RNA-seq gene expression with an ‘M1-like’ transcription signature in macrophages from intestinal biopsies of patients with IBD was reported [63,64]. Here, CCL27 is linked to inflammatory bowel disease.