c-Musculoaponeurotic fibrosarcoma(c-Maf) is another TF that is important in maintaining the ILC1:ILC3 balance; indeed, c-Maf is a direct repressor of Tbx21, leading to reduced expression of IFNγ and NKp46 in CCR6– ILC3, and promotion of RORγt, IL17A, and IL22 expression in SI LP NKp46+ and DN ILC3, as demonstrated in Rorc-Cre × Maffl/fl compared with Maffl/fl control mice [34,80]. The gene discussed is MAF; the disease is fibrosarcoma.