Microarray and Gene Ontology analyses demonstrated that forced expression of PTH-AS in PTH–nonexpressing human breast cancer T47D cells did not induce the ectopic expression of the nearby PTH gene but did significantly upregulate Janus kinase–signal transducer and activator of transcription pathway–related genes such as cancer-promoting interferon-related DNA damage resistance signature (IRDS) genes. This evidence concerns the gene PTH and breast carcinoma.