Targeted drugs such as PI3K beta inhibitors, histone acetylase inhibitors, Bruton's tyrosine kinase (BTK) inhibitors, checkpoint inhibitors (PD-1 and CTLA-4), immunomodulatory drugs (IMIDs), and BCL-2 inhibitors can be administered together with CAR T cells to overcome escape mechanisms and improve anti-tumor activity [86]. Here, BTK is linked to neoplasm.