ST8SIA2 and schizophrenia: In a novel object recognition task, both lines showed signs of impaired memory, whereas working memory, prepulse inhibition and amphetamine-induced hyperlocomotion were only affected in the St8sia2-deficient mice indicating that compromised brain development caused by the loss of ST8SIA2-dependent polysialylation can lead to schizophrenia-like psychotic behavior (Kröcher et al., 2015).