The SPICE analysis revealed the majority of SARS-CoV-2-specific T cells for both cohorts only produce one of the three cytokines tested, with TNF-α dominating the virus-specific CD4+ T cell response and IFN-γ dominating the CD8+ T cell response in those with pulmonary PASC, while RC participants’ responses were IL-2 dominant. This evidence concerns the gene CD4 and long COVID-19.