To explore our proposed KGs-guided new and repurposable candidate drugs for the treatment against BC, we considered the proposed KGs based 13 key proteins (AKR1C1, IRF9, OAS1, OAS3, SLCO2A1, NT5E, NQO1, ANGPT1, FN1, ATF6B, HPGD, BCL11A, and TP53INP1) and their regulatory 4 TFs proteins (FOXC1, FOXL1, GATA2, and JUN) as the drug target receptors and performed their docking simulation with 129 drug molecules collected from the GSCALite database and published articles (see Fig 6A). This evidence concerns the gene AKR1C1 and breast cancer.