To explore candidate drugs for breast cancer (BC), we considered 13 KGs based proteins (AKR1C1, IRF9, OAS1, OAS3, SLCO2A1, NT5E, NQO1, ANGPT1, FN1, ATF6B, HPGD, BCL11A, and TP53INP1) and its regulatory key 4 TFs proteins (FOXC1, GATA2, FOXL1 and JUN) as the m = 17 drug target receptors. This evidence concerns the gene AKR1C1 and breast cancer.