In summary, in this study, we provided the first laboratory evidence to confirm the migration route of AC L3 in nonpermissive host mice and discovered that AC larvae could induce fatal pneumonia in mice during the acute and early infection phase while interstitial pneumonia during the late infection phase; this condition was characterized by activation of Stat3/IL-6 signaling. The gene discussed is STAT3; the disease is susceptibility to pneumonia measurement.