Previous studies have reported on the relations of single-occasion traits including TC/HDL, PP, HR, CRP, BMI, LVMI, and HbA1c, with HF risk, consistent with our study findings [5–16]; this supports the established associations of a pro-inflammatory state (CRP), sympathetic hyperactivity (HR), coronary heart disease (TC/HDL, PP, BMI, LVMI, HbA1c), with the risk of incident HF. The gene discussed is CRP; the disease is coronary artery disorder.