To clarify the relationship between the SPRR1A expression and these molecular subtypes of PDAC, we next examined the expression of SPRR1A and the signature genes of the “classical” and “basal-like” subtypes described by Moffitt et al. [28] using transcriptome data of our in vitro experiments and TCGA-PAAD cases. Here, SPRR1A is linked to pancreatic adenocarcinoma.