Regarding other types of non-SCCs, including colorectal, breast cancer and diffuse large B-cell lymphoma, previous studies have reported that the SPRR1A expression was increased in 71.9% (82/114) of colorectal cancer, 53.8% (56/111) of breast cancer and 31.5% (305/967) of diffuse large B-cell lymphoma cases, and that a high expression of SPRR1A correlated with a poor prognosis [19–21]. The gene discussed is SPRR1A; the disease is breast carcinoma.