Here, we have performed a well-powered association analysis between KL-VSHET+ and five different AD endophenotypes: Aβ assessed by PET scans (n = 5,541) and CSF (n = 5,093), as well as the CSF Tau (n = 5,127), phosphorylated Tau (pTau181; n = 4,778) and sTREM2 (n = 2,123). The gene discussed is MAPT; the disease is Alzheimer disease.