The second study [30] analyzed data from 581 adults (mean age 71 years) and found no significant associations between KL-VSHET+ and cognitive decline, independent of the APOE ε4 genotype, suggesting no modifying effect of KL-VSHET+ on Aβ aggregation and APOE ε4-driven cognitive decline in preclinical AD. Here, APOE is linked to Mental deterioration.