CDH1 and cancer: To investigate potential E-cadherin dysregulation, we used image analysis to determine that, despite expressing the same level of total E-cadherin, BxGR-360C cells display a significantly lower level of E-cadherin enrichment at cell-cell junctions relative to BxPC3 cells, see S1H, S1I and S2 Figs. E-cadherin dysregulation has previously been described as a key characteristic of cancer cell invasiveness [32,33].