In line with the present findings, a study of individuals who were monitored yearly during adolescence from age 11 to 16 years, and then again at 19 and 21, reported (separate) positive relationships between either depressive symptoms or recurrent episodes of depression at a given visit and CRP at the next visit [27]; notably, only recurrent, cumulative depressive episodes were associated with CRP after accounting for covariates in that study. This evidence concerns the gene CRP and major depressive disorder.