For instance, a cohort study of participants from ages 9 to 21 reported that both depression (obtained one to two years earlier than CRP assessments) and cumulative depressive episodes were longitudinally associated with CRP, even after controlling for a range of relevant covariates (including gender, age, race, low socioeconomic status [SES], body mass index [BMI], alcohol or other drug use, and medication use [27]. This evidence concerns the gene CRP and major depressive disorder.