The present study utilized data from the Midlife in the United States (MIDUS) study to examine the association between depressive symptoms at baseline and markers of inflammation (CRP, IL-6) 11 years later in a non-clinical sample of middle aged and older adults, and whether such associations were mediated by two primary indicators of sleep disturbances (self-reported overall sleep quality and actigraphy-based sleep efficiency). Here, IL6 is linked to sleep disorder.