This enzyme appears to play an important role in the tumour invasion process through the degradation of the extracellular matrix, modulation of the immune response, and regulation of several cell signalling pathways, including the activation of tyrosine kinase receptors, especially c-Met, matrix metalloproteinases, IL-11, CXCL16, and integrin alpha-6-beta-4 [4, 13, 15]. This evidence concerns the gene CXCL16 and neoplasm.