A polymorphism in the exonic allele (g.760A) of the ALOX5 gene (which encodes for 5-lipoxygenase, an important regulator of the immune response in TB [81,82]) was associated with higher risk of TB in Ghana, an association that was stronger in infections caused by M. africanum L6 strains [83]. The gene discussed is ALOX5; the disease is tuberculosis.