HMGA2 and cryptorchidism: A 1985 retrospective study looking at closely interrelated breed groups in the dog (e.g. toy, miniature, and standard Poodles) found that the risk of cryptorchidism in the smaller version of the breed was always greater than in its larger relation, suggesting that testicular maldescent could be related to size or growth rate [6], and lending credence to the idea that the HMGA2 small size variant may be linked to cryptorchidism in the dog.