Similarly, a US population-based analysis reported that 27.9% (95% CI, 22.9%-33.0%) participants in the CKD subgroup had masked asleep hypertension.20 Among 738 White patients with treated hypertension and controlled clinic BP measurements, 48.5% patients had nighttime MUCH.32 Among 1808 untreated outpatients recruited from a hypertension clinic, Zhang et al33 reported that 11.6% patients had isolated nighttime hypertension with increased carotid intima-media thickness and urinary albumin-to-creatinine ratio compared with patients without hypertension. This evidence concerns the gene ALB and chronic kidney disease.