Δ = Delta, dex = dexamethasone, CRH = Corticotropin Realising Hormone, DDAVP = Desmopressin, CS = Cushing’s Syndrome, CD = Cushing’s Disease, pCS = pseudo-Cushing’s syndrome, ACS = Adrenal Cushing’s Syndrome, EAS = Ectopic ACTH Secretion, Se = Sensitivity, Sp = Specificity. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.