MAPT and Alzheimer disease: However, despite the fact that clinical studies have demonstrated associations between abnormal oscillatory signatures and AD proteinopathy (Nakamura et al., 2018; Smailovic et al., 2018; Pusil et al., 2019; Ranasinghe et al., 2020; Ranasinghe et al., 2021), the electrophysiological basis of aberrant excitatory and inhibitory activity of neuronal cell populations and how these relate to Aβ and tau remain largely unknown in patients with AD.