MAPT and Alzheimer disease: Preclinical AD models have demonstrated direct effects of tau and Aβ leading to impaired function in excitatory pyramidal neurons as well as inhibitory interneurons (Palop et al., 2007; Hoover et al., 2010; Sun et al., 2012; Verret et al., 2012; Palop and Mucke, 2016; Zhou et al., 2017; Busche et al., 2019; Zott et al., 2019; Harris et al., 2020; Chang et al., 2021 ).