The body mass index, endotoxin activity, and concentrations of aspartate aminotransferase, alanine amino transferase, gamma‐glutamyl transpeptidase, total cholesterol, triglycerides, low-density lipoproteins, hyaluronic acid, and type IV collagen 7s domain were significantly higher and those of platelets, albumin, and high‐density lipoproteins were significantly lower in patients with severe fibrosis NAFLD than in HCs. The gene discussed is ALB; the disease is metabolic dysfunction-associated steatotic liver disease.