DSG1 and acquired polycythemia vera: The PV disease process was once believed to be primarily linked to autoantibodies disrupting the desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1) cadherin family found on desmosomes, causing subsequent keratinocyte detachment, histologically known as acantholysis (Cirillo et al., 2012; Mavropoulos et al., 2013).