In conclusion, the combined clinical data of 35 individuals suggest that biallelic variants in ZNF142 result in a syndromic NDD most often including mild to moderate ID with variable degrees of delay in language and motor development, early‐onset seizures, behavioral challenges, hypotonia, and movement disorders with variable severity and recurrent facial features such as hypertelorism and wide nasal bridge, telecanthus, thick eyebrows with lateral sparseness, facial hypotonia, and everted lower lip vermilion. Here, ZNF142 is linked to Neurodevelopmental delay.