We found that the DDRRG signature, composed of FBXO18, MMS19, SMC4, HEXB, UBQLN4, VAV3, E2F7, EFNB1, WEE1, SAA1, SHISA5, WAC, PSMC2, PTGFRN, EIF3L and HMGA2, can independently predict the outcome of glioma patients. This evidence concerns the gene VAV3 and central nervous system cancer.