Among the 16 valuable biomarkers, 11 highly elevated genes in the high‐risk group, including SMC4, HEXB, VAV3, E2F7, EFNB1, WEE1, SAA1, SHISA5, PSMC2, PTGFRN and HMGA2, were significantly associated with poor outcome for patients with gliomas. Here, SHISA5 is linked to central nervous system cancer.