We found that the DDRRG signature, composed of FBXO18, MMS19, SMC4, HEXB, UBQLN4, VAV3, E2F7, EFNB1, WEE1, SAA1, SHISA5, WAC, PSMC2, PTGFRN, EIF3L and HMGA2, can independently predict the outcome of glioma patients. This evidence concerns the gene EFNB1 and central nervous system cancer.