The distal P1 promoter is silenced [11] in HCC but the proximal P3 promoter is demethylated and reactivated.[12] This promoter switching has also been reported in HBV infection as the HBx protein induces Igf2 expression from the P3 promoter through demethylation.[13] Transcripts derived from P3 and P4 contain a 5' untranslated region (UTR) that is a target for regulation by the IGF2BP/IMP RNA‐binding proteins which increase translation.[14] These IGF2BPs are also overexpressed in HCC,[15] so these transcripts may lead to higher IGF2 protein levels. Here, IGF2 is linked to hepatocellular carcinoma.