IGF2 and insulin signaling is suppressed by DNA damage as wild‐type p53, but not mutant p53, inhibits both the IGF1R and INSR gene promoters [43] and p53 also represses IGF2 expression.[44] The regulation is likely reciprocal as cancer‐cell secreted IGF2 represses p53 in fibroblasts potentially via AKT phosphorylation of MDM2.[45] IGF2 is an important mitogen in p53 mutant tumors as conditional deletion of Igf2 reduces tumors in p53 null mice.[46] Here we show that loss of SRSF3 caused DNA damage and activation of p53 signaling in an IGF2‐dependent manner. Here, INSR is linked to cancer.