IGF2 and hepatocellular carcinoma: IGF2 showed a greater range in mRNA expression compared to SRSF3 whose levels were relatively stable consistent with the known autoregulation of its expression.[32] ≈16% of HCC samples showed high IGF2 expression consistent with previous reports.[8] To test the effect of high IGF2 expression on outcomes, we compared survival in the group of patients in the TGCA data with IGF2 levels above the median value to samples with IGF2 levels below the median (Figure 7a).