INS and hepatocellular carcinoma: Normally the liver is not responsive to IGF2 as hepatocytes do not express the IGF1R, but loss of SRSF3 causes skipping of exon 11 of the INSR allowing IGF2 to activate insulin signaling via INSR‐A.[3, 18] The importance of this mechanism is supported by the observation that loss of the related splicing factor SRSF1 did not alter INSR splicing and did not cause HCC despite elevating IGF2.