Signatures 1 and 5 are clock‐like signatures that are related to aging; signature 3 is seen in tumors with defects in homologous recombination and is related to DSBs; signatures 6 and 20 are DNA mismatch repair signatures, and signature 12 is a liver‐specific signature of unknown etiology that is only observed in HCC. Here, CLOCK is linked to hepatocellular carcinoma.