It has been reported that IGF2 is overexpressed in HCC.[31] We had previously reported that SRSF3 protein expression is lost in HCC, and loss of SRSF3 increases IGF2 expression and predisposes to HCC.[3b] To assess whether elevated levels of IGF2 predicted outcomes, we analyzed the TCGA‐LIHC dataset (n = 424) to study the relationship between SRSF3 and IGF2 expression and patient outcomes. Here, IGF2 is linked to hepatocellular carcinoma.