PLAT and Stroke: When treated with thrombolytic agents, such as tissue plasminogen activator (tPA), long treatment times and high doses of tPA can greatly increase the risk of internal bleeding due to off‐target effects, and most notably intracranial bleeding that can lead to stroke or death.[2] To solve this problem, the interventional drug delivery and the targeted microbubble can reduce the doses of the thrombolytic agents to avoid the hemorrhage.