In addition, BHLHE41 overexpression altered the levels of EMT-related proteins in tumor tissues, and BHLHE41 overexpression significantly decreased the levels of N-cadherin, vimentin, and MMP9 and significantly increased the levels of E-cadherin in tumor tissues, which was consistent with the results of in vitro experiments and Montagner et al. [27] . This evidence concerns the gene CDH2 and neoplasm.