This study reveals that QUE can reduce the inflammatory response (TNF and IL6), inhibit endothelial cell proliferation (VEGFA) and apoptosis of podocytes (AKT1 and TP53), and suppress the AGE-induced oxidative stress by regulating the AGE-RAGE signaling pathway activated by HG to protect against podocytes injury in DN (Figure 7). This evidence concerns the gene AKT1 and liver dysplastic nodule.