Several studies have explored the relationship between the SHBG rs6259 SNP and serum SHBG concentration and PCOS risk, but they present conflicting results (Cousin et al., 2004; Bendlová et al., 2007; Ferk et al., 2007; Martinez-Garcia et al., 2012; Dai et al., 2015; Abu-Hijleh et al., 2016; Bhatnager et al., 2019; Liu et al., 2019). The gene discussed is SHBG; the disease is polycystic ovary syndrome.