As shown in Table 2, for SHBG rs6529 polymorphisms and the PCOS susceptibility, eight case-control studies involving 1625 PCOS patients and 1313 control women were included, with no significant association found under dominant model (p = 0.752, OR = 0.99, 95%CI 0.94–1.05, I2 = 60.90%, Pheterogeneity = 0.012) in the general population. This evidence concerns the gene SHBG and polycystic ovary syndrome.