All of the five studies were conducted in the Asian population (Table 2), no significant association between the CYP19A1 rs2414096 polymorphisms and the PCOS susceptibility was found under dominant model (p = 0.578, OR = 0.87, 95%CI 0.54–1.41, I2 = 95.90%, Pheterogeneity = 0.000). The gene discussed is CYP19A1; the disease is polycystic ovary syndrome.