However, a meta-analysis published by Li et al., in 2012 showed that in the overall analyses and some subgroup analyses (by race and country), the CYP17A1 rs743572 T > C polymorphisms were not associated with PCOS risk, but a significant increase in the PCOS risk was observed in studies within HWE and in small sample studies (Li et al., 2012). The gene discussed is CYP17A1; the disease is polycystic ovary syndrome.