PLOD1 and polycystic ovary syndrome: LH excess associated with PCOS may be secondary to the peripheral events within the ovary, the mechanism of neuroendocrine dysfunction resulting in an elevated LH in PCOS may be an uncoupling of hypothalamic estradiol inhibition by elevated ovarian androstenedione, while elevated LH may cause hyperandrogenemia (Doi et al., 2005; Doi, 2008).