The results showed that CYP17A1 rs743572 polymorphisms were found to be negatively associated with PCOS risk under dominant model in the general population while neither CYP19A1 rs2414096 polymorphisms nor SHBG rs6529 polymorphisms was associated with PCOS susceptibility under dominant model in the general population. The gene discussed is CYP17A1; the disease is polycystic ovary syndrome.