Candidate gene investigations provide insight into different frequency distributions in healthy and diseased populations (Douma et al., 2019); however, previous studies exploring the potential relationship between PCOS susceptibility and CYP17A1/CYP19A1/SHBG gene polymorphisms used statistically insufficient samples sizes and reported inconsistent findings (Li et al., 2012; Liao and Cao, 2020; Li et al., 2021; Sharma et al., 2021). The gene discussed is SHBG; the disease is polycystic ovary syndrome.