Previously, it is shown that SOX2 and CUX1 bind to several common target genes, including CHN1 (involved in Duane Retraction Syndrome), HOMER2 (linked to Congenital diaphragmatic hernia), HIF1AN and KCCN2, WDR37, FOXP4, ARL6 (involved in Bardet-Biedl syndrome) (49, 50), and several WNT genes in mouse mammary tumors (51). The gene discussed is HIF1AN; the disease is congenital diaphragmatic hernia.