In addition, 19 CpG island sites in the ABCA7 locus have been shown to be positively correlated with pathological AD diagnosis (Yu et al., 2015), including 12 CpG sites associated with Aβ content and 18 CpG sites associated with Tau tangle tightness (De Roeck et al., 2019). This evidence concerns the gene MAPT and Alzheimer disease.