It has been reported that HULC mediates HCC cell death by regulating miR-186/HMGA2 [14], miR-134-5p/FOXM1 axis [15], miR-200a-3p/ZEB1 axis [16], and miR-377-5p/HIF-1α [17] as well as other signaling pathways. This evidence concerns the gene HULC and hepatocellular carcinoma.