However, the functions of BID, CASP4, ZFYVE1, PRKAR1A, NPC1, TP53INP2, HSPA8, EIF2S1, and BAG1 gene have not been reported in RCC, suggesting that the validation at cellular level, as well as cellular level studies, may reveal the function of these genes in both RCC development and progression. This evidence concerns the gene EIF2S1 and renal cell carcinoma.