Patel R. et al. (2020) found that the concurrent suppression of atypical protein kinase-C (PKC) and mTOR could remarkably inhibit bladder cancer progression. The mitotic spindle is a fundamental physiological process in cells. The abnormal mitotic spindle in cancer cells might increase cellular heterogeneity, facilitating genomic instability, metastasis, and cancer stemness (Pease and Tirnauer, 2011). G2/M checkpoint is a limitation step of the cell cycle and its arrest could inhibit cell proliferation (Akaike and Chibazakura, 2020). The gene discussed is PRRT2; the disease is urinary bladder carcinoma.