PIK3R5 and acute myeloid leukemia: According to reports, HCP5 was overexpressed in AML and was positively associated with poor prognosis (Lei et al., 2020), it was significantly overexpressed in AML, and HCP5 upregulation promoted the progression of AML cells via the miR-1291/PIK3R5 axis (Liu Y. et al., 2021).