Among these signal pathways, the PI3K/Akt/mTOR signaling pathway has been reported to be aberrantly hyperactivated in multiple cancers such as AML, which is required to sustain the oncogenic potential of leukemia stem cell populations (Darici et al., 2020; Nepstad et al., 2020). The gene discussed is AKT1; the disease is acute myeloid leukemia.