If there is progression in these patients, including progressive impairment of pulmonary function, a major radiographic progression (such as the development of cavities or fibrosis), glucocorticoids and immunosuppressants can be given after determining virus inactivity, or even cytokine monoclonal antibody therapy, such as the anti-TNF monoclonal antibody infliximab, is mainly used for the treatment of sarcoidosis as off-label third-line therapy (7). The gene discussed is TNF; the disease is sarcoidosis.