CD8A and injury: In trauma patients, naïve B cells, CD8+ T cells, CD4+ memory resting T cells, activated CD4+ memory T cells, activated natural killer (NK) cells, M2 macrophages, and resting dendritic cells were significantly reduced, whereas plasma cells, regulatory T cells regulatory (Tregs), M0 macrophages, M1 macrophages, resting mast cells, activated mast cells, and neutrophils were significantly upregulated (Figure 2A).