In patients with sepsis, naïve B-cells, memory B-cells, CD8+ T cells, naïve CD4+ T cells, CD4+ memory resting T cells, activated NK cells, and resting dendritic cells were significantly downregulated, whereas plasma cells, Tregs, γδ T cells, M0 macrophages, M1 macrophages, M2 macrophages, mast cells, and eosinophils were significantly upregulated (Figure 2B). This evidence concerns the gene CD4 and Sepsis.