For example, NK cell activation was significantly upregulated in both trauma and sepsis patients, with 11 of 14 immune-related common genes (ACVR1B, CCR3, HGF, IL1R2, KL, LCN2, LTF, MMP9, OSM, PLSCR1, and S100P) significantly associated with activated NK cells in trauma patients (Figure 3A) and 10 of 14 immune-related common genes (ACVR1B, CAMP, IL1R2, KL, LTF, MMP9, OSM, PLSCR1, S100A12, and S100P) significantly associated with activated NK cells in sepsis patients (Figure 3B). This evidence concerns the gene IL1R2 and Sepsis.