IL6 and COVID-19: Nonetheless, from accumulating evidence indicates that SARS-CoV-2 and several proinflammatory cytokines, including IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, and IFN-γ, can cross the blood–brain barrier, suggesting a highly probable para- or post- infectious immune-mediated etiology of COVID-19-associated CNS injuries (142, 143).