Because administration of 2 subsequent doses of 5x107 HK C. neoformans Δsgl1 also conferred complete host protection to the WT strain even during CD4-deficiency (Figure 2), we sought to investigate the efficacy of host protection after vaccination with either live or HK C. neoformans Δsgl1 via alternations to our preventative vaccination model during immunocompetency and CD4-deficiency. Here, CD4 is linked to hyperinsulinemic hypoglycemia, familial, 4.