CD123-ENG.IL15 T-cells retained a naïve/TSCM-like phenotype and expressed low levels of exhaustion markers and, in vivo, had superior anti-AML activity compared to CD123-ENG T-cells not only in xenografts derived from established cell lines but also in those derived from leukemias of a primary patient. This evidence concerns the gene IL15 and acute myeloid leukemia.