TNF and Alzheimer disease: The GSEA results showed that compared with the ND controls, the Hippo signaling pathway, JAK-STAT signaling pathway, Notch signaling pathway, and TNF signaling pathway were increased in AD patients (Figure 3C), while GABAergic synapse, synaptic vesicle cycle, oxidative phosphorylation, and retrograde endocannabinoid signaling were decreased (Figure 3D).