BRD4 and Cornelia de Lange syndrome: Proper DNA repair is imperative for neural development (Frank et al., 2000; Gao et al., 2000) and mutation of proteins involved in DNA damage repair are often associated with neurodevelopmental defects [reviewed in Lee et al. (2016)], suggesting that defective DNA repair may also contribute to the CdLS-like phenotype of BRD4 heterozygous LoF patients.