Among them, tuckahoe and cassia twig can downregulate HIF-1α expression in lesions and then inhibit the combination of HIF-1α and VEGF under hypoxia, decrease the rate of angiogenesis by regulating the HIF-1α-VEGF signaling pathway, and avoid the acceleration of tumor growth through transcription and posttranscriptional control after HIF-1 binds to target genes. The gene discussed is HIF1A; the disease is neoplasm.