TNF and neoplasm: In the formula, Pinellia tuber contains rich baicalein, a substance that is able to downregulate VEGF level and upregulate Rb-1 expression, resulting in inhibition of tumor angiogenesis, and the stigmasterol in Pinellia tuber can destroy the TNF-α-VEGFR-2 axis and then inhibit the proliferation of endothelial cells.