Significant differences were found in age (p<.001), tumor size (p=.004), complications (p<.007), LVI (p=.002), stage (p<.001), and chemotherapy (p=.009) between the low CEA-pre and high CEA-pre groups, whereas sex (p=.103), BMI (p=.397), smoking (p=.241), tumor location (p=.327), histologic grade (p=.652), and number of retrieved lymph nodes (p=.332) were not significantly different between the two groups. This evidence concerns the gene CEACAM5 and neoplasm.