POLD4 and gastric cancer: For example, in gastric cancer, it has been shown that circ_0026359 is overexpressed and correlated with cisplatin resistance and poor survival in gastric cancer patients, and conversely, deletion of circ_0026359 enhances miR-1200 activity, which reduces the expression level of POLD4 and thus reduces the resistance of gastric cancer cells to cisplatin.