In recent years, it has been shown that circRNAs can influence tumor cell resistance by enhancing EMT; for example, circ_001680 and circ-NOTCH1 are elevated in colorectal cancer (CRC) and gastric cancer (GC), respectively, and both these circRNAs can promote cancer stem cell (CSC) expansion via EMT (11, 173). This evidence concerns the gene NOTCH1 and gastric cancer.