showed that in lung adenocarcinoma cells, circRNA CCDC66 increases SUMOlyation modifications related to the HGF-MET signaling pathway and epidermal growth factor receptor (EGFR)-controlled SAE2 through association with EMT and thus affects the resistance of tumor cells to tyrosine kinase inhibitors (TKIs) targeting EGFR (180). This evidence concerns the gene MET and lung adenocarcinoma.