E2F1 and gastric cancer: For example, in gastric cancer, circFAM73A increases the expression of HMG (high mobility group) A2 through miR-490-3p, HMGA2 plays a dichotomous role in regulating circFAM73A ex-pression, i.e., HMGA2 facilitates the transcriptional acti-vation of FAM73A by E2F1 and elevates the efficiency of circFAM73A circularization by HNRNPL, HMGA2 promotes stem cell-like properties and cell malignancy in GC cells (164).