YBX1 and hepatocellular carcinoma: It should be pointed out that the previously mentioned circRNA-SORE mediates the drug resistance of hepatocellular carcinoma to sorafenib by stabilizing the YBX1 protein; in fact, it does not involve gene copy number and activation, but rather, circRNA directly plays a role in the process of protein stability and degradation.YBX1 is a kind of RNA binding protein (RBP).