CircRNA can be negatively correlated with the generation of tumor drug resistance,For example, circ_0000079 induces the ribonucleic acid binding protein FXR1 to block the formation of the FXR1/PrCKI complex and reduces its promoting effects on NSCLC cell invasion and cisplatin resistance; it was shown that circ_0000079 (CiR79) levels were significantly downregulated in NSCLC patients, especially in cisplatin-resistant NSCLC patients, and that reduced circ_0000079 levels were significantly associated with overall survival in NSCLC patients. The gene discussed is FXR1; the disease is neoplasm.