showed that in lung adenocarcinoma cells, circRNA CCDC66 increases SUMOlyation modifications related to the HGF-MET signaling pathway and epidermal growth factor receptor (EGFR)-controlled SAE2 through association with EMT and thus affects the resistance of tumor cells to tyrosine kinase inhibitors (TKIs) targeting EGFR (180). Here, EGFR is linked to lung adenocarcinoma.