PFKFB3 and neoplasm: In tumor cells, glucose uptake is dramatically increased by the upregulation of glycolytic enzymes such as hexokinase 2 (HK2), 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3/4 (Pfkfb3/4), lactate dehydrogenase A (LDHA) and the expression of glucose transporters (Gluts, particularly Glut1) to fuel aerobic glycolysis and provide cellular metabolites for the generation of new biomass, which ultimately stimulates tumor development and progression.19, 20