In tumor cells, glucose uptake is dramatically increased by the upregulation of glycolytic enzymes such as hexokinase 2 (HK2), 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3/4 (Pfkfb3/4), lactate dehydrogenase A (LDHA) and the expression of glucose transporters (Gluts, particularly Glut1) to fuel aerobic glycolysis and provide cellular metabolites for the generation of new biomass, which ultimately stimulates tumor development and progression.19, 20. The gene discussed is LDHA; the disease is neoplasm.