Moreover, we identified the cortical bone architecture of Ctsk‐Cre;Trp53f/f/Rb1f/f mice at 1.5, 3.5, and 7 months and found that the thickness and destruction of cortical bone were gradually aggravated, parallel to the progression level of osteosarcoma (Figure 3H). The gene discussed is CTSK; the disease is osteosarcoma.