We hypothesized that the dynamics of typical indicators of systemic inflammation, such as tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10), or biomarkers of tissue hypoxia and necrosis, such as big endothelin (bET) and high-mobility group box 1 protein (HMGB1), may be associated with numerical pSOFA score changes and that this relationship can therefore be useful in recognizing the development of organ dysfunctions in experimental sepsis. The gene discussed is HMGB1; the disease is Sepsis.