This systematic review and meta-analysis aimed to assess the efficacy and safety of anti-VEGF monotherapy for ROP treatment using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.<h4>Methods</h4>We searched the Medline, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases. Here, VEGFA is linked to retinopathy of prematurity.