CD1D and neoplasm: Despite their low numbers, iNKT cells are normal components of both mouse and human TMEs (24, 34, 47, 55), where they can efficiently reprogram tumor opposing state irrespectively of the CD1d expression by cancer cells, by restraining the immunosuppressive functions of myelomonocytic cells such as TAMs, MDSC and TANs populations (83–85), as summarized in Table 1.