By investigating at the same time a transgenic mouse model of CLL and patients with stable or progressive disease, we showed that iNKT cells delay the onset and progression of the leukemia by remodeling the supporting niche of the leukemia cells through the selective elimination of the CD1d-expressing M2-like macrophage population called nurse-like cells (NLCs) (24), which sustain CLL cell survival (24, 91). The gene discussed is CD1D; the disease is B-cell chronic lymphocytic leukemia.