Of note, the main CD4+ and CD4− iNKT cell subsets were not equally effective in tumor control: in fact, liver-derived CD4− iNKT cells were found to be the main mediators of tumor immune surveillance in vivo, by sustaining a TH1-type CD8+ T and NK cell-mediated immune response via IFNγ production (23). This evidence concerns the gene IFNG and neoplasm.