iNKT cells promote the anti-tumor immune response through the maturation of CD1d+ DCs and the secretion of IFNγ and IL-12, in turn leading to the activation of anti-tumor CD4+ and CD8+ T cells and of NK cells, which ultimately cooperate in the elimination of both MHC-positive and -negative cancer cells (32, 59). Here, CD4 is linked to neoplasm.