The upregulation of CX43 by the transient receptor potential vanoxalate-4 (TRPV4) may be involved in the pathophysiological process of epilepsy (Men et al., 2019), and the specific CX43 mimic peptide and TAT-Gap19 can reduce spontaneous seizures by inhibiting the function of GJ channels/hemi-channels of CX43 between astrocytes (Delvaeye et al., 2018; Walrave et al., 2018). The gene discussed is TRPV4; the disease is epilepsy.